Back & Nerve Pain

Long-lasting pain is one of the most common reasons people see a doctor, and one of the hardest to treat well. Researchers are testing medicines, devices and exercise programs to change that.

A woman sitting on the edge of a bed with one hand pressed to her lower back
  • Low back pain
  • Sciatica
  • Diabetic nerve pain
  • Shingles pain
  • Neck pain

What studies here look at

Pain studies often compare a new medicine with a placebo or with an existing one over a period of weeks, asking you to score your pain each day. Some test treatments that are not pills at all, such as a patch, an injection near the spine or a small device worn on the skin.

Nerve pain research focuses on the burning, tingling and numbness that can follow diabetes or shingles. Other studies look at how movement, sleep and mood affect pain, and test structured programs of exercise or talking therapy.

Who studies often look for

  • Adults with low back pain that has lasted more than a few months

  • People with pain that runs down one leg, often called sciatica

  • People with diabetes who have burning or tingling in their feet

  • Adults with pain that stayed after a case of shingles

Each study sets its own requirements. Read this as the people who tend to be asked, not as a checklist.

What taking part might involve

Four things studies in this area often ask of the people who take part.

  • A daily pain score

    A number from zero to ten each evening, entered on a phone or a paper diary.

  • Movement checks

    Simple tests of how far you can bend, walk or stand, timed by the team.

  • Changes to pain medicine

    Some studies ask you to pause or adjust what you take, and say how beforehand.

  • Questionnaires

    Questions about sleep, mood and daily tasks, because pain touches all of them.

Questions for the study team

Take these to your first call, and note the answers.

  • Which of my current pain medicines can I keep taking?
  • What can I use if my pain flares during the study?
  • Will I need any injections or scans, and what are they like?

Hear about studies in this area

Sign up with Back & Nerve Pain as your area and your ZIP code, and we will text you when a study near you lines up.

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See what is recruiting today

ClinicalTrials.gov is the public U.S. list of studies. This search shows recruiting studies for low back pain.

Open the registry search